Yes you can engrave or score clear Acrylic with a diode laser here is how to do it. I made a full Youtube video showing each step.
I do recommend you run a material test on your machine to get the very best settings for your machine.
I used MDF but black paper works well too just be sure to run you test with the same background to get the best settings.
This is important you can see my video on some pointers for what not to do with Acrylic
Blow off if you can try not to wipe or touch it.
Lightly sand the edge of the Acrylic